Fisetin targets YB-1/RSK axis independent of its effect on ERK signaling: insights from in vitro and in vivo melanoma models

Abstract The anti-proliferative activity of dietary flavonoid fisetin has been validated in various cancer models. Establishing its precise mechanism of action has proved somewhat challenging given the multiplicity of its targets. We demonstrated that YB-1 promotes epithelial-to-mesenchymal transiti...

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Autores principales: Mario Sechi, Rahul K. Lall, Saheed O Afolabi, Anant Singh, Dinesh C. Joshi, Shing-Yan Chiu, Hasan Mukhtar, Deeba N. Syed
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/5e2df20b2938453aa0b4f7b03494c319
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