Activity dependent degeneration explains hub vulnerability in Alzheimer's disease.

Brain connectivity studies have revealed that highly connected 'hub' regions are particularly vulnerable to Alzheimer pathology: they show marked amyloid-β deposition at an early stage. Recently, excessive local neuronal activity has been shown to increase amyloid deposition. In this study...

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Autores principales: Willem de Haan, Katherine Mott, Elisabeth C W van Straaten, Philip Scheltens, Cornelis J Stam
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/5e6033ca571a4359abd2e59099bb3e0b
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