ABCB1 protects bat cells from DNA damage induced by genotoxic compounds

Bats possess an extended lifespan compared to most mammals of their size, and have a low cancer incidence. Here the authors show that several bat species exhibit resistance to genotoxic agents that is in part attributable to high expression of the ABCB1 transporter.

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Autores principales:	Javier Koh, Yoko Itahana, Ian H. Mendenhall, Dolyce Low, Eunice Xin Yi Soh, Alvin Kunyao Guo, Yok Teng Chionh, Lin-Fa Wang, Koji Itahana
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5e6e7ed316d54035a1bd7923fee4f815
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spelling	oai:doaj.org-article:5e6e7ed316d54035a1bd7923fee4f8152021-12-02T14:40:17ZABCB1 protects bat cells from DNA damage induced by genotoxic compounds10.1038/s41467-019-10495-42041-1723https://doaj.org/article/5e6e7ed316d54035a1bd7923fee4f8152019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10495-4https://doaj.org/toc/2041-1723Bats possess an extended lifespan compared to most mammals of their size, and have a low cancer incidence. Here the authors show that several bat species exhibit resistance to genotoxic agents that is in part attributable to high expression of the ABCB1 transporter.Javier KohYoko ItahanaIan H. MendenhallDolyce LowEunice Xin Yi SohAlvin Kunyao GuoYok Teng ChionhLin-Fa WangKoji ItahanaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Javier Koh Yoko Itahana Ian H. Mendenhall Dolyce Low Eunice Xin Yi Soh Alvin Kunyao Guo Yok Teng Chionh Lin-Fa Wang Koji Itahana ABCB1 protects bat cells from DNA damage induced by genotoxic compounds
description	Bats possess an extended lifespan compared to most mammals of their size, and have a low cancer incidence. Here the authors show that several bat species exhibit resistance to genotoxic agents that is in part attributable to high expression of the ABCB1 transporter.
format	article
author	Javier Koh Yoko Itahana Ian H. Mendenhall Dolyce Low Eunice Xin Yi Soh Alvin Kunyao Guo Yok Teng Chionh Lin-Fa Wang Koji Itahana
author_facet	Javier Koh Yoko Itahana Ian H. Mendenhall Dolyce Low Eunice Xin Yi Soh Alvin Kunyao Guo Yok Teng Chionh Lin-Fa Wang Koji Itahana
author_sort	Javier Koh
title	ABCB1 protects bat cells from DNA damage induced by genotoxic compounds
title_short	ABCB1 protects bat cells from DNA damage induced by genotoxic compounds
title_full	ABCB1 protects bat cells from DNA damage induced by genotoxic compounds
title_fullStr	ABCB1 protects bat cells from DNA damage induced by genotoxic compounds
title_full_unstemmed	ABCB1 protects bat cells from DNA damage induced by genotoxic compounds
title_sort	abcb1 protects bat cells from dna damage induced by genotoxic compounds
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5e6e7ed316d54035a1bd7923fee4f815
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ABCB1 protects bat cells from DNA damage induced by genotoxic compounds

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