Metformin impairs mitochondrial function in skeletal muscle of both lean and diabetic rats in a dose-dependent manner.

Metformin is a widely prescribed drug for the treatment of type 2 diabetes. Previous studies have demonstrated in vitro that metformin specifically inhibits Complex I of the mitochondrial respiratory chain. This seems contraindicative since muscle mitochondrial dysfunction has been linked to the pat...

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Autores principales: Bart Wessels, Jolita Ciapaite, Nicole M A van den Broek, Klaas Nicolay, Jeanine J Prompers
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/5e6ecce7cfde4841a6cdae3d73e4a2cd
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