Enantioselective acyl transfer catalysis by a combination of common catalytic motifs and electrostatic interactions

Nucleophilic catalysts are widely used for acyl transfer reactions, but chiral variants can be difficult to design or synthesise. Here, the authors report catalysts with chirality imparted from a binaphtyl moiety with tert-alcohol unit that show both high activity and enantioselectivity for a range...

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Autores principales: Hiroki Mandai, Kazuki Fujii, Hiroshi Yasuhara, Kenko Abe, Koichi Mitsudo, Toshinobu Korenaga, Seiji Suga
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/5e7f35966c0a4cdb94c85844b7113628
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Sumario:Nucleophilic catalysts are widely used for acyl transfer reactions, but chiral variants can be difficult to design or synthesise. Here, the authors report catalysts with chirality imparted from a binaphtyl moiety with tert-alcohol unit that show both high activity and enantioselectivity for a range of acyl transfer reactions.