Enantioselective acyl transfer catalysis by a combination of common catalytic motifs and electrostatic interactions

Nucleophilic catalysts are widely used for acyl transfer reactions, but chiral variants can be difficult to design or synthesise. Here, the authors report catalysts with chirality imparted from a binaphtyl moiety with tert-alcohol unit that show both high activity and enantioselectivity for a range...

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Autores principales:	Hiroki Mandai, Kazuki Fujii, Hiroshi Yasuhara, Kenko Abe, Koichi Mitsudo, Toshinobu Korenaga, Seiji Suga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5e7f35966c0a4cdb94c85844b7113628
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spelling	oai:doaj.org-article:5e7f35966c0a4cdb94c85844b71136282021-12-02T17:31:48ZEnantioselective acyl transfer catalysis by a combination of common catalytic motifs and electrostatic interactions10.1038/ncomms112972041-1723https://doaj.org/article/5e7f35966c0a4cdb94c85844b71136282016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11297https://doaj.org/toc/2041-1723Nucleophilic catalysts are widely used for acyl transfer reactions, but chiral variants can be difficult to design or synthesise. Here, the authors report catalysts with chirality imparted from a binaphtyl moiety with tert-alcohol unit that show both high activity and enantioselectivity for a range of acyl transfer reactions.Hiroki MandaiKazuki FujiiHiroshi YasuharaKenko AbeKoichi MitsudoToshinobu KorenagaSeiji SugaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hiroki Mandai Kazuki Fujii Hiroshi Yasuhara Kenko Abe Koichi Mitsudo Toshinobu Korenaga Seiji Suga Enantioselective acyl transfer catalysis by a combination of common catalytic motifs and electrostatic interactions
description	Nucleophilic catalysts are widely used for acyl transfer reactions, but chiral variants can be difficult to design or synthesise. Here, the authors report catalysts with chirality imparted from a binaphtyl moiety with tert-alcohol unit that show both high activity and enantioselectivity for a range of acyl transfer reactions.
format	article
author	Hiroki Mandai Kazuki Fujii Hiroshi Yasuhara Kenko Abe Koichi Mitsudo Toshinobu Korenaga Seiji Suga
author_facet	Hiroki Mandai Kazuki Fujii Hiroshi Yasuhara Kenko Abe Koichi Mitsudo Toshinobu Korenaga Seiji Suga
author_sort	Hiroki Mandai
title	Enantioselective acyl transfer catalysis by a combination of common catalytic motifs and electrostatic interactions
title_short	Enantioselective acyl transfer catalysis by a combination of common catalytic motifs and electrostatic interactions
title_full	Enantioselective acyl transfer catalysis by a combination of common catalytic motifs and electrostatic interactions
title_fullStr	Enantioselective acyl transfer catalysis by a combination of common catalytic motifs and electrostatic interactions
title_full_unstemmed	Enantioselective acyl transfer catalysis by a combination of common catalytic motifs and electrostatic interactions
title_sort	enantioselective acyl transfer catalysis by a combination of common catalytic motifs and electrostatic interactions
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5e7f35966c0a4cdb94c85844b7113628
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Enantioselective acyl transfer catalysis by a combination of common catalytic motifs and electrostatic interactions

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