CHARACTERISTICS OF SIGNALING PATHWAYS MEDIATING A CYTOTOXIC EFFECT OF DENDRITIC CELLS UPON ACTIVATED Т LYMPHOCYTES AND NK CELLS
Abstract. Cytotoxic/pro-apoptogenic effects of IFNα-induced dendritic cells (IFN-DCs) directed against Т-lymphocytes and NK cells were investigated in healthy donors. Using an allogenic MLC system, it was revealed that IFN-DCs induce apoptosis of both activated CD4+ and CD8+ T-lymphocytes, and NK ce...
Guardado en:
Autores principales: | , , , , , |
---|---|
Formato: | article |
Lenguaje: | RU |
Publicado: |
SPb RAACI
2014
|
Materias: | |
Acceso en línea: | https://doaj.org/article/5ebb326fc78d4bac95d260975d016164 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:5ebb326fc78d4bac95d260975d016164 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:5ebb326fc78d4bac95d260975d0161642021-11-18T08:03:40ZCHARACTERISTICS OF SIGNALING PATHWAYS MEDIATING A CYTOTOXIC EFFECT OF DENDRITIC CELLS UPON ACTIVATED Т LYMPHOCYTES AND NK CELLS1563-06252313-741X10.15789/1563-0625-2012-1-2-43-50https://doaj.org/article/5ebb326fc78d4bac95d260975d0161642014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/294https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Cytotoxic/pro-apoptogenic effects of IFNα-induced dendritic cells (IFN-DCs) directed against Т-lymphocytes and NK cells were investigated in healthy donors. Using an allogenic MLC system, it was revealed that IFN-DCs induce apoptosis of both activated CD4+ and CD8+ T-lymphocytes, and NK cells. Apoptosis of CD4+ and CD8+ T-lymphocytes induced by their interaction with IFN-DCs was mediated by various signaling pathways. In particular, activated CD4+Т-lymphocytes were most sensitive to TRAIL- и Fas/ FasL-transduction pathways, whereas activated CD8+ T-lymphocytes were induced to apoptosis via TNFα-mediated pathway. PD-1/B7-H1-signaling pathway also played a distinct role in cytotoxic activity of IFNDCs towards both types of T lymphocytes and activated NK cells. The pro-apoptogenic/cytotoxic activity of IFN-DC against activated lymphocytes may be regarded as a mechanism of a feedback regulation aimed at restriction of immune response and maintenance of immune homeostasis. Moreover, upregulation of proapoptogenic molecules on DCs under pathological conditions may lead to suppression of antigen-specific response, thus contributing to the disease progression.T. V. TyrinovaO. Yu. LeplinaM. A. TikhonovaL. V. SakhnoA. A. OstaninE. R. ChernykhSPb RAACIarticledendritic cellstrailfaslb7-h1/pd-1т-lymphocytesnk-cells, apoptosisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 1-2, Pp 43-50 (2014) |
institution |
DOAJ |
collection |
DOAJ |
language |
RU |
topic |
dendritic cells trail fasl b7-h1/pd-1 т-lymphocytes nk-cells, apoptosis Immunologic diseases. Allergy RC581-607 |
spellingShingle |
dendritic cells trail fasl b7-h1/pd-1 т-lymphocytes nk-cells, apoptosis Immunologic diseases. Allergy RC581-607 T. V. Tyrinova O. Yu. Leplina M. A. Tikhonova L. V. Sakhno A. A. Ostanin E. R. Chernykh CHARACTERISTICS OF SIGNALING PATHWAYS MEDIATING A CYTOTOXIC EFFECT OF DENDRITIC CELLS UPON ACTIVATED Т LYMPHOCYTES AND NK CELLS |
description |
Abstract. Cytotoxic/pro-apoptogenic effects of IFNα-induced dendritic cells (IFN-DCs) directed against Т-lymphocytes and NK cells were investigated in healthy donors. Using an allogenic MLC system, it was revealed that IFN-DCs induce apoptosis of both activated CD4+ and CD8+ T-lymphocytes, and NK cells. Apoptosis of CD4+ and CD8+ T-lymphocytes induced by their interaction with IFN-DCs was mediated by various signaling pathways. In particular, activated CD4+Т-lymphocytes were most sensitive to TRAIL- и Fas/ FasL-transduction pathways, whereas activated CD8+ T-lymphocytes were induced to apoptosis via TNFα-mediated pathway. PD-1/B7-H1-signaling pathway also played a distinct role in cytotoxic activity of IFNDCs towards both types of T lymphocytes and activated NK cells. The pro-apoptogenic/cytotoxic activity of IFN-DC against activated lymphocytes may be regarded as a mechanism of a feedback regulation aimed at restriction of immune response and maintenance of immune homeostasis. Moreover, upregulation of proapoptogenic molecules on DCs under pathological conditions may lead to suppression of antigen-specific response, thus contributing to the disease progression. |
format |
article |
author |
T. V. Tyrinova O. Yu. Leplina M. A. Tikhonova L. V. Sakhno A. A. Ostanin E. R. Chernykh |
author_facet |
T. V. Tyrinova O. Yu. Leplina M. A. Tikhonova L. V. Sakhno A. A. Ostanin E. R. Chernykh |
author_sort |
T. V. Tyrinova |
title |
CHARACTERISTICS OF SIGNALING PATHWAYS MEDIATING A CYTOTOXIC EFFECT OF DENDRITIC CELLS UPON ACTIVATED Т LYMPHOCYTES AND NK CELLS |
title_short |
CHARACTERISTICS OF SIGNALING PATHWAYS MEDIATING A CYTOTOXIC EFFECT OF DENDRITIC CELLS UPON ACTIVATED Т LYMPHOCYTES AND NK CELLS |
title_full |
CHARACTERISTICS OF SIGNALING PATHWAYS MEDIATING A CYTOTOXIC EFFECT OF DENDRITIC CELLS UPON ACTIVATED Т LYMPHOCYTES AND NK CELLS |
title_fullStr |
CHARACTERISTICS OF SIGNALING PATHWAYS MEDIATING A CYTOTOXIC EFFECT OF DENDRITIC CELLS UPON ACTIVATED Т LYMPHOCYTES AND NK CELLS |
title_full_unstemmed |
CHARACTERISTICS OF SIGNALING PATHWAYS MEDIATING A CYTOTOXIC EFFECT OF DENDRITIC CELLS UPON ACTIVATED Т LYMPHOCYTES AND NK CELLS |
title_sort |
characteristics of signaling pathways mediating a cytotoxic effect of dendritic cells upon activated т lymphocytes and nk cells |
publisher |
SPb RAACI |
publishDate |
2014 |
url |
https://doaj.org/article/5ebb326fc78d4bac95d260975d016164 |
work_keys_str_mv |
AT tvtyrinova characteristicsofsignalingpathwaysmediatingacytotoxiceffectofdendriticcellsuponactivatedtlymphocytesandnkcells AT oyuleplina characteristicsofsignalingpathwaysmediatingacytotoxiceffectofdendriticcellsuponactivatedtlymphocytesandnkcells AT matikhonova characteristicsofsignalingpathwaysmediatingacytotoxiceffectofdendriticcellsuponactivatedtlymphocytesandnkcells AT lvsakhno characteristicsofsignalingpathwaysmediatingacytotoxiceffectofdendriticcellsuponactivatedtlymphocytesandnkcells AT aaostanin characteristicsofsignalingpathwaysmediatingacytotoxiceffectofdendriticcellsuponactivatedtlymphocytesandnkcells AT erchernykh characteristicsofsignalingpathwaysmediatingacytotoxiceffectofdendriticcellsuponactivatedtlymphocytesandnkcells |
_version_ |
1718422478532902912 |