HIV Silencing and Inducibility Are Heterogeneous and Are Affected by Factors Intrinsic to the Virus

ABSTRACT Transcriptionally silent HIV proviruses form the major obstacle to eradicating HIV. Many studies of HIV latency have focused on the cellular mechanisms that maintain silencing of proviral DNA. Here we show that viral sequence variation affecting replicative ability leads to variable rates o...

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Auteurs principaux: Nicholas J. Norton, Hoi Ping Mok, Fatima Sharif, Jack C. Hirst, Andrew M. L. Lever
Format: article
Langue:EN
Publié: American Society for Microbiology 2019
Sujets:
HIV
Accès en ligne:https://doaj.org/article/5ec59ece3af14869b31e20e379fa66bf
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