HIV Silencing and Inducibility Are Heterogeneous and Are Affected by Factors Intrinsic to the Virus

ABSTRACT Transcriptionally silent HIV proviruses form the major obstacle to eradicating HIV. Many studies of HIV latency have focused on the cellular mechanisms that maintain silencing of proviral DNA. Here we show that viral sequence variation affecting replicative ability leads to variable rates o...

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Bibliographic Details
Main Authors: Nicholas J. Norton, Hoi Ping Mok, Fatima Sharif, Jack C. Hirst, Andrew M. L. Lever
Format: article
Language:EN
Published: American Society for Microbiology 2019
Subjects:
HIV
Online Access:https://doaj.org/article/5ec59ece3af14869b31e20e379fa66bf
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