Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer

Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer

Gemcitabine is used to treat gallbaldder cancer but patient responses are variable. Here, the authors use a genome-wide CRISPR screen and identify the translational elongator protein ELP5 as a protein that is important for mediating gemcitabine-induced apoptosis.

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Détails bibliographiques
Auteurs principaux: Sunwang Xu, Ming Zhan, Cen Jiang, Min He, Linhua Yang, Hui Shen, Shuai Huang, Xince Huang, Ruirong Lin, Yongheng Shi, Qiang Liu, Wei Chen, Man Mohan, Jian Wang
Format: article
Langue:EN
Publié: Nature Portfolio 2019
Sujets:
Science
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Accès en ligne:https://doaj.org/article/5ece9e4bbc994ad5973c54027993a069
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Internet

https://doaj.org/article/5ece9e4bbc994ad5973c54027993a069

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