Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer

Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer

Gemcitabine is used to treat gallbaldder cancer but patient responses are variable. Here, the authors use a genome-wide CRISPR screen and identify the translational elongator protein ELP5 as a protein that is important for mediating gemcitabine-induced apoptosis.

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Autores principales: Sunwang Xu, Ming Zhan, Cen Jiang, Min He, Linhua Yang, Hui Shen, Shuai Huang, Xince Huang, Ruirong Lin, Yongheng Shi, Qiang Liu, Wei Chen, Man Mohan, Jian Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/5ece9e4bbc994ad5973c54027993a069
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spelling oai:doaj.org-article:5ece9e4bbc994ad5973c54027993a0692021-12-02T15:35:08ZGenome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer10.1038/s41467-019-13420-x2041-1723https://doaj.org/article/5ece9e4bbc994ad5973c54027993a0692019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13420-xhttps://doaj.org/toc/2041-1723Gemcitabine is used to treat gallbaldder cancer but patient responses are variable. Here, the authors use a genome-wide CRISPR screen and identify the translational elongator protein ELP5 as a protein that is important for mediating gemcitabine-induced apoptosis.Sunwang XuMing ZhanCen JiangMin HeLinhua YangHui ShenShuai HuangXince HuangRuirong LinYongheng ShiQiang LiuWei ChenMan MohanJian WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sunwang Xu
Ming Zhan
Cen Jiang
Min He
Linhua Yang
Hui Shen
Shuai Huang
Xince Huang
Ruirong Lin
Yongheng Shi
Qiang Liu
Wei Chen
Man Mohan
Jian Wang
Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer
description Gemcitabine is used to treat gallbaldder cancer but patient responses are variable. Here, the authors use a genome-wide CRISPR screen and identify the translational elongator protein ELP5 as a protein that is important for mediating gemcitabine-induced apoptosis.
format article
author Sunwang Xu
Ming Zhan
Cen Jiang
Min He
Linhua Yang
Hui Shen
Shuai Huang
Xince Huang
Ruirong Lin
Yongheng Shi
Qiang Liu
Wei Chen
Man Mohan
Jian Wang
author_facet Sunwang Xu
Ming Zhan
Cen Jiang
Min He
Linhua Yang
Hui Shen
Shuai Huang
Xince Huang
Ruirong Lin
Yongheng Shi
Qiang Liu
Wei Chen
Man Mohan
Jian Wang
author_sort Sunwang Xu
title Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer
title_short Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer
title_full Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer
title_fullStr Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer
title_full_unstemmed Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer
title_sort genome-wide crispr screen identifies elp5 as a determinant of gemcitabine sensitivity in gallbladder cancer
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/5ece9e4bbc994ad5973c54027993a069
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AT xincehuang genomewidecrisprscreenidentifieselp5asadeterminantofgemcitabinesensitivityingallbladdercancer
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