Acute EPA-induced learning and memory impairment in mice is prevented by DHA
Acute administration of EPA impairs learning and memory and hippocampal LTP in mice that was mediated through enhancing GABAergic transmission via the 5-HT6R. DHA can prevent EPA-induced impairments at a ratio of EPA to DHA similar to that in marine fish oil via the 5-HT2CR.
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Nature Portfolio
2020
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oai:doaj.org-article:5edff60ffe5c4a1aa0e972347df5b4492021-12-02T17:31:09ZAcute EPA-induced learning and memory impairment in mice is prevented by DHA10.1038/s41467-020-19255-12041-1723https://doaj.org/article/5edff60ffe5c4a1aa0e972347df5b4492020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19255-1https://doaj.org/toc/2041-1723Acute administration of EPA impairs learning and memory and hippocampal LTP in mice that was mediated through enhancing GABAergic transmission via the 5-HT6R. DHA can prevent EPA-induced impairments at a ratio of EPA to DHA similar to that in marine fish oil via the 5-HT2CR.Ji-Hong LiuQian WangQiang-Long YouZe-Lin LiNeng-Yuan HuYan WangZeng-Lin JinShu-Ji LiXiao-Wen LiJian-Ming YangXin-Hong ZhuYi-Fan DaiJiang-Ping XuXiao-Chun BaiTian-Ming GaoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ji-Hong Liu Qian Wang Qiang-Long You Ze-Lin Li Neng-Yuan Hu Yan Wang Zeng-Lin Jin Shu-Ji Li Xiao-Wen Li Jian-Ming Yang Xin-Hong Zhu Yi-Fan Dai Jiang-Ping Xu Xiao-Chun Bai Tian-Ming Gao Acute EPA-induced learning and memory impairment in mice is prevented by DHA |
| description |
Acute administration of EPA impairs learning and memory and hippocampal LTP in mice that was mediated through enhancing GABAergic transmission via the 5-HT6R. DHA can prevent EPA-induced impairments at a ratio of EPA to DHA similar to that in marine fish oil via the 5-HT2CR. |
| format |
article |
| author |
Ji-Hong Liu Qian Wang Qiang-Long You Ze-Lin Li Neng-Yuan Hu Yan Wang Zeng-Lin Jin Shu-Ji Li Xiao-Wen Li Jian-Ming Yang Xin-Hong Zhu Yi-Fan Dai Jiang-Ping Xu Xiao-Chun Bai Tian-Ming Gao |
| author_facet |
Ji-Hong Liu Qian Wang Qiang-Long You Ze-Lin Li Neng-Yuan Hu Yan Wang Zeng-Lin Jin Shu-Ji Li Xiao-Wen Li Jian-Ming Yang Xin-Hong Zhu Yi-Fan Dai Jiang-Ping Xu Xiao-Chun Bai Tian-Ming Gao |
| author_sort |
Ji-Hong Liu |
| title |
Acute EPA-induced learning and memory impairment in mice is prevented by DHA |
| title_short |
Acute EPA-induced learning and memory impairment in mice is prevented by DHA |
| title_full |
Acute EPA-induced learning and memory impairment in mice is prevented by DHA |
| title_fullStr |
Acute EPA-induced learning and memory impairment in mice is prevented by DHA |
| title_full_unstemmed |
Acute EPA-induced learning and memory impairment in mice is prevented by DHA |
| title_sort |
acute epa-induced learning and memory impairment in mice is prevented by dha |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/5edff60ffe5c4a1aa0e972347df5b449 |
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