Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation

Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation

Lumbar disc herniation (LDH) can cause persistent sciatica, and in some cases surgery is required to relieve symptoms. Here, the authors carry out a genome-wide association study using microdiscectomy as an indicator of severe LDH, and find a locus on chromosome 8 associated with this condition.

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Auteurs principaux: Gyda Bjornsdottir, Stefania Benonisdottir, Gardar Sveinbjornsson, Unnur Styrkarsdottir, Gudmar Thorleifsson, G. Bragi Walters, Aron Bjornsson, Ingvar H. Olafsson, Elfar Ulfarsson, Arnor Vikingsson, Ragnheidur Hansdottir, Karl O. Karlsson, Thorunn Rafnar, Ingileif Jonsdottir, Michael L. Frigge, Augustine Kong, Asmundur Oddsson, Gisli Masson, Olafur T. Magnusson, Tomas Gudbjartsson, Hreinn Stefansson, Patrick Sulem, Daniel Gudbjartsson, Unnur Thorsteinsdottir, Thorgeir E. Thorgeirsson, Kari Stefansson
Format: article
Langue:EN
Publié: Nature Portfolio 2017
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/5ef612302b2040f09104c825b57b2116
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https://doaj.org/article/5ef612302b2040f09104c825b57b2116

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