Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation
Lumbar disc herniation (LDH) can cause persistent sciatica, and in some cases surgery is required to relieve symptoms. Here, the authors carry out a genome-wide association study using microdiscectomy as an indicator of severe LDH, and find a locus on chromosome 8 associated with this condition.
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Nature Portfolio
2017
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oai:doaj.org-article:5ef612302b2040f09104c825b57b21162021-12-02T17:06:31ZSequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation10.1038/ncomms142652041-1723https://doaj.org/article/5ef612302b2040f09104c825b57b21162017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14265https://doaj.org/toc/2041-1723Lumbar disc herniation (LDH) can cause persistent sciatica, and in some cases surgery is required to relieve symptoms. Here, the authors carry out a genome-wide association study using microdiscectomy as an indicator of severe LDH, and find a locus on chromosome 8 associated with this condition.Gyda BjornsdottirStefania BenonisdottirGardar SveinbjornssonUnnur StyrkarsdottirGudmar ThorleifssonG. Bragi WaltersAron BjornssonIngvar H. OlafssonElfar UlfarssonArnor VikingssonRagnheidur HansdottirKarl O. KarlssonThorunn RafnarIngileif JonsdottirMichael L. FriggeAugustine KongAsmundur OddssonGisli MassonOlafur T. MagnussonTomas GudbjartssonHreinn StefanssonPatrick SulemDaniel GudbjartssonUnnur ThorsteinsdottirThorgeir E. ThorgeirssonKari StefanssonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017) |
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EN |
| topic |
Science Q |
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Science Q Gyda Bjornsdottir Stefania Benonisdottir Gardar Sveinbjornsson Unnur Styrkarsdottir Gudmar Thorleifsson G. Bragi Walters Aron Bjornsson Ingvar H. Olafsson Elfar Ulfarsson Arnor Vikingsson Ragnheidur Hansdottir Karl O. Karlsson Thorunn Rafnar Ingileif Jonsdottir Michael L. Frigge Augustine Kong Asmundur Oddsson Gisli Masson Olafur T. Magnusson Tomas Gudbjartsson Hreinn Stefansson Patrick Sulem Daniel Gudbjartsson Unnur Thorsteinsdottir Thorgeir E. Thorgeirsson Kari Stefansson Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation |
| description |
Lumbar disc herniation (LDH) can cause persistent sciatica, and in some cases surgery is required to relieve symptoms. Here, the authors carry out a genome-wide association study using microdiscectomy as an indicator of severe LDH, and find a locus on chromosome 8 associated with this condition. |
| format |
article |
| author |
Gyda Bjornsdottir Stefania Benonisdottir Gardar Sveinbjornsson Unnur Styrkarsdottir Gudmar Thorleifsson G. Bragi Walters Aron Bjornsson Ingvar H. Olafsson Elfar Ulfarsson Arnor Vikingsson Ragnheidur Hansdottir Karl O. Karlsson Thorunn Rafnar Ingileif Jonsdottir Michael L. Frigge Augustine Kong Asmundur Oddsson Gisli Masson Olafur T. Magnusson Tomas Gudbjartsson Hreinn Stefansson Patrick Sulem Daniel Gudbjartsson Unnur Thorsteinsdottir Thorgeir E. Thorgeirsson Kari Stefansson |
| author_facet |
Gyda Bjornsdottir Stefania Benonisdottir Gardar Sveinbjornsson Unnur Styrkarsdottir Gudmar Thorleifsson G. Bragi Walters Aron Bjornsson Ingvar H. Olafsson Elfar Ulfarsson Arnor Vikingsson Ragnheidur Hansdottir Karl O. Karlsson Thorunn Rafnar Ingileif Jonsdottir Michael L. Frigge Augustine Kong Asmundur Oddsson Gisli Masson Olafur T. Magnusson Tomas Gudbjartsson Hreinn Stefansson Patrick Sulem Daniel Gudbjartsson Unnur Thorsteinsdottir Thorgeir E. Thorgeirsson Kari Stefansson |
| author_sort |
Gyda Bjornsdottir |
| title |
Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation |
| title_short |
Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation |
| title_full |
Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation |
| title_fullStr |
Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation |
| title_full_unstemmed |
Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation |
| title_sort |
sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/5ef612302b2040f09104c825b57b2116 |
| work_keys_str_mv |
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| _version_ |
1718381554798952448 |