Antibody repertoires in humanized NOD-scid-IL2Rγ(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse.

Antibody repertoires in humanized NOD-scid-IL2Rγ(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse.

Immunodeficient mice reconstituted with human hematopoietic stem cells enable the in vivo study of human hematopoiesis. In particular, NOD-scid-IL2Rγ(null) engrafted mice have been shown to have reasonable levels of T and B cell repopulation and can mount T-cell dependent responses; however, antigen...

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Bibliographic Details
Main Authors: Gregory C Ippolito, Kam Hon Hoi, Sai T Reddy, Sean M Carroll, Xin Ge, Tobias Rogosch, Michael Zemlin, Leonard D Shultz, Andrew D Ellington, Carla L Vandenberg, George Georgiou
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/5ef8b4675a504e6093b82d723c0e81f4
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