Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons

The physiological role of the olfactory marker protein (OMP) has been elusive. Here, the authors demonstrate that OMP buffers cAMP and modulates cAMP-gated channel activity upon sensory stimulation, maintaining neuronal firing during odour-source searching.

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Autores principales:	Noriyuki Nakashima, Kie Nakashima, Akiko Taura, Akiko Takaku-Nakashima, Harunori Ohmori, Makoto Takano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5f004020de71409998164819cc158a1c
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spelling	oai:doaj.org-article:5f004020de71409998164819cc158a1c2021-12-02T14:42:14ZOlfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons10.1038/s41467-020-15917-22041-1723https://doaj.org/article/5f004020de71409998164819cc158a1c2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15917-2https://doaj.org/toc/2041-1723The physiological role of the olfactory marker protein (OMP) has been elusive. Here, the authors demonstrate that OMP buffers cAMP and modulates cAMP-gated channel activity upon sensory stimulation, maintaining neuronal firing during odour-source searching.Noriyuki NakashimaKie NakashimaAkiko TauraAkiko Takaku-NakashimaHarunori OhmoriMakoto TakanoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Noriyuki Nakashima Kie Nakashima Akiko Taura Akiko Takaku-Nakashima Harunori Ohmori Makoto Takano Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons
description	The physiological role of the olfactory marker protein (OMP) has been elusive. Here, the authors demonstrate that OMP buffers cAMP and modulates cAMP-gated channel activity upon sensory stimulation, maintaining neuronal firing during odour-source searching.
format	article
author	Noriyuki Nakashima Kie Nakashima Akiko Taura Akiko Takaku-Nakashima Harunori Ohmori Makoto Takano
author_facet	Noriyuki Nakashima Kie Nakashima Akiko Taura Akiko Takaku-Nakashima Harunori Ohmori Makoto Takano
author_sort	Noriyuki Nakashima
title	Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons
title_short	Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons
title_full	Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons
title_fullStr	Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons
title_full_unstemmed	Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons
title_sort	olfactory marker protein directly buffers camp to avoid depolarization-induced silencing of olfactory receptor neurons
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5f004020de71409998164819cc158a1c
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Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons

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