Acute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy

Differentiation therapy induces the maturation and clearance of acute myeloid leukemia cells. Here, using a mouse model, the authors show that a specific lineage of mature leukemia-derived cells persists during remission and is responsible for disease relapse.

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Autores principales:	Steven Ngo, Ethan P. Oxley, Margherita Ghisi, Maximilian M. Garwood, Mark D. McKenzie, Helen L. Mitchell, Peter Kanellakis, Olivia Susanto, Michael J. Hickey, Andrew C. Perkins, Benjamin T. Kile, Ross A. Dickins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5f04ec10aa484e7aa4589412ec95bdf7
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spelling	oai:doaj.org-article:5f04ec10aa484e7aa4589412ec95bdf72021-11-14T12:36:28ZAcute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy10.1038/s41467-021-26849-w2041-1723https://doaj.org/article/5f04ec10aa484e7aa4589412ec95bdf72021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26849-whttps://doaj.org/toc/2041-1723Differentiation therapy induces the maturation and clearance of acute myeloid leukemia cells. Here, using a mouse model, the authors show that a specific lineage of mature leukemia-derived cells persists during remission and is responsible for disease relapse.Steven NgoEthan P. OxleyMargherita GhisiMaximilian M. GarwoodMark D. McKenzieHelen L. MitchellPeter KanellakisOlivia SusantoMichael J. HickeyAndrew C. PerkinsBenjamin T. KileRoss A. DickinsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Steven Ngo Ethan P. Oxley Margherita Ghisi Maximilian M. Garwood Mark D. McKenzie Helen L. Mitchell Peter Kanellakis Olivia Susanto Michael J. Hickey Andrew C. Perkins Benjamin T. Kile Ross A. Dickins Acute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy
description	Differentiation therapy induces the maturation and clearance of acute myeloid leukemia cells. Here, using a mouse model, the authors show that a specific lineage of mature leukemia-derived cells persists during remission and is responsible for disease relapse.
format	article
author	Steven Ngo Ethan P. Oxley Margherita Ghisi Maximilian M. Garwood Mark D. McKenzie Helen L. Mitchell Peter Kanellakis Olivia Susanto Michael J. Hickey Andrew C. Perkins Benjamin T. Kile Ross A. Dickins
author_facet	Steven Ngo Ethan P. Oxley Margherita Ghisi Maximilian M. Garwood Mark D. McKenzie Helen L. Mitchell Peter Kanellakis Olivia Susanto Michael J. Hickey Andrew C. Perkins Benjamin T. Kile Ross A. Dickins
author_sort	Steven Ngo
title	Acute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy
title_short	Acute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy
title_full	Acute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy
title_fullStr	Acute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy
title_full_unstemmed	Acute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy
title_sort	acute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5f04ec10aa484e7aa4589412ec95bdf7
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Acute myeloid leukemia maturation lineage influences residual disease and relapse following differentiation therapy

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