Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α

Macrophages in the tumour microenvironment (TME) acquire tumour-promoting functions upon M2 polarization. Here the authors show, in a mouse model of glioblastoma, that endothelial cells in the TME induce macrophage M2 polarization via IL-6 and that depletion of endothelial IL-6 improves survival.

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Autores principales:	Qirui Wang, Zhenqiang He, Menggui Huang, Tianrun Liu, Yanling Wang, Haineng Xu, Hao Duan, Peihong Ma, Lin Zhang, Scott S. Zamvil, Juan Hidalgo, Zhenfeng Zhang, Donald M. O’Rourke, Nadia Dahmane, Steven Brem, Yonggao Mou, Yanqing Gong, Yi Fan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5f37ad77abf54c4e89ce8111d4283ac7
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spelling	oai:doaj.org-article:5f37ad77abf54c4e89ce8111d4283ac72021-12-02T15:33:56ZVascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α10.1038/s41467-018-03050-02041-1723https://doaj.org/article/5f37ad77abf54c4e89ce8111d4283ac72018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03050-0https://doaj.org/toc/2041-1723Macrophages in the tumour microenvironment (TME) acquire tumour-promoting functions upon M2 polarization. Here the authors show, in a mouse model of glioblastoma, that endothelial cells in the TME induce macrophage M2 polarization via IL-6 and that depletion of endothelial IL-6 improves survival.Qirui WangZhenqiang HeMenggui HuangTianrun LiuYanling WangHaineng XuHao DuanPeihong MaLin ZhangScott S. ZamvilJuan HidalgoZhenfeng ZhangDonald M. O’RourkeNadia DahmaneSteven BremYonggao MouYanqing GongYi FanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qirui Wang Zhenqiang He Menggui Huang Tianrun Liu Yanling Wang Haineng Xu Hao Duan Peihong Ma Lin Zhang Scott S. Zamvil Juan Hidalgo Zhenfeng Zhang Donald M. O’Rourke Nadia Dahmane Steven Brem Yonggao Mou Yanqing Gong Yi Fan Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
description	Macrophages in the tumour microenvironment (TME) acquire tumour-promoting functions upon M2 polarization. Here the authors show, in a mouse model of glioblastoma, that endothelial cells in the TME induce macrophage M2 polarization via IL-6 and that depletion of endothelial IL-6 improves survival.
format	article
author	Qirui Wang Zhenqiang He Menggui Huang Tianrun Liu Yanling Wang Haineng Xu Hao Duan Peihong Ma Lin Zhang Scott S. Zamvil Juan Hidalgo Zhenfeng Zhang Donald M. O’Rourke Nadia Dahmane Steven Brem Yonggao Mou Yanqing Gong Yi Fan
author_facet	Qirui Wang Zhenqiang He Menggui Huang Tianrun Liu Yanling Wang Haineng Xu Hao Duan Peihong Ma Lin Zhang Scott S. Zamvil Juan Hidalgo Zhenfeng Zhang Donald M. O’Rourke Nadia Dahmane Steven Brem Yonggao Mou Yanqing Gong Yi Fan
author_sort	Qirui Wang
title	Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
title_short	Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
title_full	Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
title_fullStr	Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
title_full_unstemmed	Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
title_sort	vascular niche il-6 induces alternative macrophage activation in glioblastoma through hif-2α
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5f37ad77abf54c4e89ce8111d4283ac7
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Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α

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