Acitretin reverses early functional network degradation in a mouse model of familial Alzheimer’s disease

Acitretin reverses early functional network degradation in a mouse model of familial Alzheimer’s disease

Abstract Aberrant activity of local functional networks underlies memory and cognition deficits in Alzheimer’s disease (AD). Hyperactivity was observed in microcircuits of mice AD-models showing plaques, and also recently in early stage AD mutants prior to amyloid deposition. However, early function...

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Main Authors: Eduardo Rosales Jubal, Miriam Schwalm, Malena dos Santos Guilherme, Florian Schuck, Sven Reinhardt, Amanda Tose, Zeke Barger, Mona K. Roesler, Nicolas Ruffini, Anna Wierczeiko, Michael J. Schmeisser, Ulrich Schmitt, Kristina Endres, Albrecht Stroh
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/5f4ceae1b11d437c87d1b329fa7fb0a8
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https://doaj.org/article/5f4ceae1b11d437c87d1b329fa7fb0a8

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