Modulation of Aneuploidy in <italic toggle="yes">Leishmania donovani</italic> during Adaptation to Different <italic toggle="yes">In Vitro</italic> and <italic toggle="yes">In Vivo</italic> Environments and Its Impact on Gene Expression

Modulation of Aneuploidy in <italic toggle="yes">Leishmania donovani</italic> during Adaptation to Different <italic toggle="yes">In Vitro</italic> and <italic toggle="yes">In Vivo</italic> Environments and Its Impact on Gene Expression

ABSTRACT Aneuploidy is usually deleterious in multicellular organisms but appears to be tolerated and potentially beneficial in unicellular organisms, including pathogens. Leishmania, a major protozoan parasite, is emerging as a new model for aneuploidy, since in vitro-cultivated strains are highly...

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Autores principales: F. Dumetz, H. Imamura, M. Sanders, V. Seblova, J. Myskova, P. Pescher, M. Vanaerschot, C. J. Meehan, B. Cuypers, G. De Muylder, G. F. Späth, G. Bussotti, J. R. Vermeesch, M. Berriman, J. A. Cotton, P. Volf, J. C. Dujardin, M. A. Domagalska
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
Leishmania
aneuploidy
gene dosage
genomics
life cycle
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/5f56f02b61fd42dfa374a4c66d46b7e9
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