Hypoxia induces an immunodominant target of tuberculosis specific T cells absent from common BCG vaccines.

Hypoxia induces an immunodominant target of tuberculosis specific T cells absent from common BCG vaccines.

M. tuberculosis (MTB) species-specific antigenic determinants of the human T cell response are important for immunodiagnosis and vaccination. As hypoxia is a stimulus in chronic tuberculosis infection, we analyzed transcriptional profiles of MTB subject to 168 hours of hypoxia to test the hypothesis...

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Bibliographic Details
Main Authors: Hannah Priyadarshini Gideon, Katalin Andrea Wilkinson, Tige R Rustad, Tolu Oni, Heinner Guio, Robert Andrew Kozak, David R Sherman, Graeme Meintjes, Marcel A Behr, Hans Martin Vordermeier, Douglas Brownlee Young, Robert John Wilkinson
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2010
Subjects:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/5f7c112149f143e6abf37c61a78902fa
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https://doaj.org/article/5f7c112149f143e6abf37c61a78902fa

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