Intramyocardial transplantation and tracking of human mesenchymal stem cells in a novel intra-uterine pre-immune fetal sheep myocardial infarction model: a proof of concept study.

Intramyocardial transplantation and tracking of human mesenchymal stem cells in a novel intra-uterine pre-immune fetal sheep myocardial infarction model: a proof of concept study.

Although stem-cell therapies have been suggested for cardiac-regeneration after myocardial-infarction (MI), key-questions regarding the in-vivo cell-fate remain unknown. While most available animal-models require immunosuppressive-therapy when applying human cells, the fetal-sheep being pre-immune u...

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Bibliographic Details
Main Authors: Maximilian Y Emmert, Benedikt Weber, Petra Wolint, Thomas Frauenfelder, Steffen M Zeisberger, Luc Behr, Sebastien Sammut, Jacques Scherman, Chad E Brokopp, Ruth Schwartländer, Viola Vogel, Peter Vogt, Jürg Grünenfelder, Hatem Alkadhi, Volkmar Falk, Andreas Boss, Simon P Hoerstrup
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/5fba4efe39af4c2b8a27005f84126fbb
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