Redesigning metabolism based on orthogonality principles

Growth-coupled designs for chemical production are limited by native metabolic networks’ optimality for growth. Here, the authors introduce pathway orthogonality as a measure of the independence of biomass and chemical production pathways, identify metabolic valves that allow substrate utilization t...

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Autores principales: Aditya Vikram Pandit, Shyam Srinivasan, Radhakrishnan Mahadevan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/5fcc9a50e6a74fc7a3de77700c2ed0d3
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