Redesigning metabolism based on orthogonality principles

Growth-coupled designs for chemical production are limited by native metabolic networks’ optimality for growth. Here, the authors introduce pathway orthogonality as a measure of the independence of biomass and chemical production pathways, identify metabolic valves that allow substrate utilization t...

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Main Authors:	Aditya Vikram Pandit, Shyam Srinivasan, Radhakrishnan Mahadevan
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/5fcc9a50e6a74fc7a3de77700c2ed0d3
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id	oai:doaj.org-article:5fcc9a50e6a74fc7a3de77700c2ed0d3
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spelling	oai:doaj.org-article:5fcc9a50e6a74fc7a3de77700c2ed0d32021-12-02T17:06:13ZRedesigning metabolism based on orthogonality principles10.1038/ncomms151882041-1723https://doaj.org/article/5fcc9a50e6a74fc7a3de77700c2ed0d32017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15188https://doaj.org/toc/2041-1723Growth-coupled designs for chemical production are limited by native metabolic networks’ optimality for growth. Here, the authors introduce pathway orthogonality as a measure of the independence of biomass and chemical production pathways, identify metabolic valves that allow substrate utilization to be switched between the two, and demonstrate advantages of orthogonal designs.Aditya Vikram PanditShyam SrinivasanRadhakrishnan MahadevanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aditya Vikram Pandit Shyam Srinivasan Radhakrishnan Mahadevan Redesigning metabolism based on orthogonality principles
description	Growth-coupled designs for chemical production are limited by native metabolic networks’ optimality for growth. Here, the authors introduce pathway orthogonality as a measure of the independence of biomass and chemical production pathways, identify metabolic valves that allow substrate utilization to be switched between the two, and demonstrate advantages of orthogonal designs.
format	article
author	Aditya Vikram Pandit Shyam Srinivasan Radhakrishnan Mahadevan
author_facet	Aditya Vikram Pandit Shyam Srinivasan Radhakrishnan Mahadevan
author_sort	Aditya Vikram Pandit
title	Redesigning metabolism based on orthogonality principles
title_short	Redesigning metabolism based on orthogonality principles
title_full	Redesigning metabolism based on orthogonality principles
title_fullStr	Redesigning metabolism based on orthogonality principles
title_full_unstemmed	Redesigning metabolism based on orthogonality principles
title_sort	redesigning metabolism based on orthogonality principles
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5fcc9a50e6a74fc7a3de77700c2ed0d3
work_keys_str_mv	AT adityavikrampandit redesigningmetabolismbasedonorthogonalityprinciples AT shyamsrinivasan redesigningmetabolismbasedonorthogonalityprinciples AT radhakrishnanmahadevan redesigningmetabolismbasedonorthogonalityprinciples
_version_	1718381675795185664

Redesigning metabolism based on orthogonality principles

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