Binding of Host Cell Surface Protein Disulfide Isomerase by <named-content content-type="genus-species">Anaplasma phagocytophilum</named-content> Asp14 Enables Pathogen Infection

Binding of Host Cell Surface Protein Disulfide Isomerase by <named-content content-type="genus-species">Anaplasma phagocytophilum</named-content> Asp14 Enables Pathogen Infection

ABSTRACT Diverse intracellular pathogens rely on eukaryotic cell surface disulfide reductases to invade host cells. Pharmacologic inhibition of these enzymes is cytotoxic, making it impractical for treatment. Identifying and mechanistically dissecting microbial proteins that co-opt surface reductase...

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Bibliographic Details
Main Authors: Ryan S. Green, Waheeda A. Naimi, Lee D. Oliver, Nathaniel O’Bier, Jaehyung Cho, Daniel H. Conrad, Rebecca K. Martin, Richard T. Marconi, Jason A. Carlyon
Format: article
Language:EN
Published: American Society for Microbiology 2020
Subjects:
adhesin
Anaplasma phagocytophilum
obligate intracellular bacteria
protein disulfide isomerase
host-pathogen interactions
Microbiology
QR1-502
Online Access:https://doaj.org/article/5fcfb0454aa64878b57f1f16d651b6f8
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https://doaj.org/article/5fcfb0454aa64878b57f1f16d651b6f8

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