Dynamic changes in gene-to-gene regulatory networks in response to SARS-CoV-2 infection

Abstract The current pandemic of SARS-CoV-2 has caused extensive damage to society. The characterization of SARS-CoV-2 profiles has been addressed by researchers globally with the aim of resolving this disruptive crisis. This investigation process is indispensable to understand how SARS-CoV-2 behave...

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Autores principales:	Yoshihisa Tanaka, Kako Higashihara, Mai Adachi Nakazawa, Fumiyoshi Yamashita, Yoshinori Tamada, Yasushi Okuno
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5fe2c81e065e4d34a240b474c1d2a8fb
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spelling	oai:doaj.org-article:5fe2c81e065e4d34a240b474c1d2a8fb2021-12-02T15:49:53ZDynamic changes in gene-to-gene regulatory networks in response to SARS-CoV-2 infection10.1038/s41598-021-90556-12045-2322https://doaj.org/article/5fe2c81e065e4d34a240b474c1d2a8fb2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90556-1https://doaj.org/toc/2045-2322Abstract The current pandemic of SARS-CoV-2 has caused extensive damage to society. The characterization of SARS-CoV-2 profiles has been addressed by researchers globally with the aim of resolving this disruptive crisis. This investigation process is indispensable to understand how SARS-CoV-2 behaves in human host cells. However, little is known about the systematic molecular mechanisms involved in the effects of SARS-CoV-2 infection on human host cells. Here, we present gene-to-gene regulatory networks in response to SARS-CoV-2 using a Bayesian network. We examined the dynamic changes in the SARS-CoV-2-purturbated networks established by our proposed framework for gene network analysis, thus revealing that interferon signaling gradually switched to the subsequent inflammatory cytokine signaling cascades. Furthermore, we succeeded in capturing a COVID-19 patient-specific network in which transduction of these signals was concurrently induced. This enabled us to explore the local regulatory systems influenced by SARS-CoV-2 in host cells more precisely at an individual level. Our panel of network analyses has provided new insights into SARS-CoV-2 research from the perspective of cellular systems.Yoshihisa TanakaKako HigashiharaMai Adachi NakazawaFumiyoshi YamashitaYoshinori TamadaYasushi OkunoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoshihisa Tanaka Kako Higashihara Mai Adachi Nakazawa Fumiyoshi Yamashita Yoshinori Tamada Yasushi Okuno Dynamic changes in gene-to-gene regulatory networks in response to SARS-CoV-2 infection
description	Abstract The current pandemic of SARS-CoV-2 has caused extensive damage to society. The characterization of SARS-CoV-2 profiles has been addressed by researchers globally with the aim of resolving this disruptive crisis. This investigation process is indispensable to understand how SARS-CoV-2 behaves in human host cells. However, little is known about the systematic molecular mechanisms involved in the effects of SARS-CoV-2 infection on human host cells. Here, we present gene-to-gene regulatory networks in response to SARS-CoV-2 using a Bayesian network. We examined the dynamic changes in the SARS-CoV-2-purturbated networks established by our proposed framework for gene network analysis, thus revealing that interferon signaling gradually switched to the subsequent inflammatory cytokine signaling cascades. Furthermore, we succeeded in capturing a COVID-19 patient-specific network in which transduction of these signals was concurrently induced. This enabled us to explore the local regulatory systems influenced by SARS-CoV-2 in host cells more precisely at an individual level. Our panel of network analyses has provided new insights into SARS-CoV-2 research from the perspective of cellular systems.
format	article
author	Yoshihisa Tanaka Kako Higashihara Mai Adachi Nakazawa Fumiyoshi Yamashita Yoshinori Tamada Yasushi Okuno
author_facet	Yoshihisa Tanaka Kako Higashihara Mai Adachi Nakazawa Fumiyoshi Yamashita Yoshinori Tamada Yasushi Okuno
author_sort	Yoshihisa Tanaka
title	Dynamic changes in gene-to-gene regulatory networks in response to SARS-CoV-2 infection
title_short	Dynamic changes in gene-to-gene regulatory networks in response to SARS-CoV-2 infection
title_full	Dynamic changes in gene-to-gene regulatory networks in response to SARS-CoV-2 infection
title_fullStr	Dynamic changes in gene-to-gene regulatory networks in response to SARS-CoV-2 infection
title_full_unstemmed	Dynamic changes in gene-to-gene regulatory networks in response to SARS-CoV-2 infection
title_sort	dynamic changes in gene-to-gene regulatory networks in response to sars-cov-2 infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5fe2c81e065e4d34a240b474c1d2a8fb
work_keys_str_mv	AT yoshihisatanaka dynamicchangesingenetogeneregulatorynetworksinresponsetosarscov2infection AT kakohigashihara dynamicchangesingenetogeneregulatorynetworksinresponsetosarscov2infection AT maiadachinakazawa dynamicchangesingenetogeneregulatorynetworksinresponsetosarscov2infection AT fumiyoshiyamashita dynamicchangesingenetogeneregulatorynetworksinresponsetosarscov2infection AT yoshinoritamada dynamicchangesingenetogeneregulatorynetworksinresponsetosarscov2infection AT yasushiokuno dynamicchangesingenetogeneregulatorynetworksinresponsetosarscov2infection
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Dynamic changes in gene-to-gene regulatory networks in response to SARS-CoV-2 infection

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