MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size

It is unclear how and why axonal mitochondria are kept so small in axons. Authors show here that MFF-mediated fission is required for determining the size of mitochondria both entering and along the axon, and this is critical for mitochondrial calcium uptake capacity, neurotransmitter release proper...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Tommy L. Lewis, Seok-Kyu Kwon, Annie Lee, Reuben Shaw, Franck Polleux
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Q
Acceso en línea:https://doaj.org/article/6011499af941422d9a5a9a83b3117271
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!