MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size

MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size

It is unclear how and why axonal mitochondria are kept so small in axons. Authors show here that MFF-mediated fission is required for determining the size of mitochondria both entering and along the axon, and this is critical for mitochondrial calcium uptake capacity, neurotransmitter release proper...

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Autores principales: Tommy L. Lewis, Seok-Kyu Kwon, Annie Lee, Reuben Shaw, Franck Polleux
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/6011499af941422d9a5a9a83b3117271
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spelling oai:doaj.org-article:6011499af941422d9a5a9a83b31172712021-12-02T15:34:25ZMFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size10.1038/s41467-018-07416-22041-1723https://doaj.org/article/6011499af941422d9a5a9a83b31172712018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07416-2https://doaj.org/toc/2041-1723It is unclear how and why axonal mitochondria are kept so small in axons. Authors show here that MFF-mediated fission is required for determining the size of mitochondria both entering and along the axon, and this is critical for mitochondrial calcium uptake capacity, neurotransmitter release properties and axon branching.Tommy L. LewisSeok-Kyu KwonAnnie LeeReuben ShawFranck PolleuxNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tommy L. Lewis
Seok-Kyu Kwon
Annie Lee
Reuben Shaw
Franck Polleux
MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size
description It is unclear how and why axonal mitochondria are kept so small in axons. Authors show here that MFF-mediated fission is required for determining the size of mitochondria both entering and along the axon, and this is critical for mitochondrial calcium uptake capacity, neurotransmitter release properties and axon branching.
format article
author Tommy L. Lewis
Seok-Kyu Kwon
Annie Lee
Reuben Shaw
Franck Polleux
author_facet Tommy L. Lewis
Seok-Kyu Kwon
Annie Lee
Reuben Shaw
Franck Polleux
author_sort Tommy L. Lewis
title MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size
title_short MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size
title_full MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size
title_fullStr MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size
title_full_unstemmed MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size
title_sort mff-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/6011499af941422d9a5a9a83b3117271
work_keys_str_mv AT tommyllewis mffdependentmitochondrialfissionregulatespresynapticreleaseandaxonbranchingbylimitingaxonalmitochondriasize
AT seokkyukwon mffdependentmitochondrialfissionregulatespresynapticreleaseandaxonbranchingbylimitingaxonalmitochondriasize
AT annielee mffdependentmitochondrialfissionregulatespresynapticreleaseandaxonbranchingbylimitingaxonalmitochondriasize
AT reubenshaw mffdependentmitochondrialfissionregulatespresynapticreleaseandaxonbranchingbylimitingaxonalmitochondriasize
AT franckpolleux mffdependentmitochondrialfissionregulatespresynapticreleaseandaxonbranchingbylimitingaxonalmitochondriasize
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