Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease
Osteocytes are the master regulatory cells within the skeleton. Here, the authors map the transcriptome of osteocytes from diverse skeletal sites, ages and between sexes and identify an osteocyte transcriptome signature associated with rare skeletal disorders and common complex skeletal diseases.
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Nature Portfolio
2021
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oai:doaj.org-article:60182d9a653b4b4d9d0b7b34378bcb3e2021-12-02T14:29:01ZOsteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease10.1038/s41467-021-22517-12041-1723https://doaj.org/article/60182d9a653b4b4d9d0b7b34378bcb3e2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22517-1https://doaj.org/toc/2041-1723Osteocytes are the master regulatory cells within the skeleton. Here, the authors map the transcriptome of osteocytes from diverse skeletal sites, ages and between sexes and identify an osteocyte transcriptome signature associated with rare skeletal disorders and common complex skeletal diseases.Scott E. YoultenJohn P. KempJohn G. LoganElena J. GhirardelloClaudio M. SergioMichael R. G. DackSiobhan E. GuilfoyleVictoria D. LeitchNatalie C. ButterfieldDavide Komla-EbriRyan C. ChaiAlexander P. CorrJames T. SmithSindhu T. MohantyJohn A. MorrisMichelle M. McDonaldJulian M. W. QuinnAmelia R. McGladeNenad BartonicekMatt JanssonKonstantinos HatzikotoulasMelita D. IrvingAna Beleza-MeirelesFernando RivadeneiraEmma DuncanJ. Brent RichardsDavid J. AdamsChristopher J. LelliottRobert BrinkTri Giang PhanJohn A. EismanDavid M. EvansEleftheria ZegginiPaul A. BaldockJ. H. Duncan BassettGraham R. WilliamsPeter I. CroucherNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-21 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
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Science Q |
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Science Q Scott E. Youlten John P. Kemp John G. Logan Elena J. Ghirardello Claudio M. Sergio Michael R. G. Dack Siobhan E. Guilfoyle Victoria D. Leitch Natalie C. Butterfield Davide Komla-Ebri Ryan C. Chai Alexander P. Corr James T. Smith Sindhu T. Mohanty John A. Morris Michelle M. McDonald Julian M. W. Quinn Amelia R. McGlade Nenad Bartonicek Matt Jansson Konstantinos Hatzikotoulas Melita D. Irving Ana Beleza-Meireles Fernando Rivadeneira Emma Duncan J. Brent Richards David J. Adams Christopher J. Lelliott Robert Brink Tri Giang Phan John A. Eisman David M. Evans Eleftheria Zeggini Paul A. Baldock J. H. Duncan Bassett Graham R. Williams Peter I. Croucher Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease |
| description |
Osteocytes are the master regulatory cells within the skeleton. Here, the authors map the transcriptome of osteocytes from diverse skeletal sites, ages and between sexes and identify an osteocyte transcriptome signature associated with rare skeletal disorders and common complex skeletal diseases. |
| format |
article |
| author |
Scott E. Youlten John P. Kemp John G. Logan Elena J. Ghirardello Claudio M. Sergio Michael R. G. Dack Siobhan E. Guilfoyle Victoria D. Leitch Natalie C. Butterfield Davide Komla-Ebri Ryan C. Chai Alexander P. Corr James T. Smith Sindhu T. Mohanty John A. Morris Michelle M. McDonald Julian M. W. Quinn Amelia R. McGlade Nenad Bartonicek Matt Jansson Konstantinos Hatzikotoulas Melita D. Irving Ana Beleza-Meireles Fernando Rivadeneira Emma Duncan J. Brent Richards David J. Adams Christopher J. Lelliott Robert Brink Tri Giang Phan John A. Eisman David M. Evans Eleftheria Zeggini Paul A. Baldock J. H. Duncan Bassett Graham R. Williams Peter I. Croucher |
| author_facet |
Scott E. Youlten John P. Kemp John G. Logan Elena J. Ghirardello Claudio M. Sergio Michael R. G. Dack Siobhan E. Guilfoyle Victoria D. Leitch Natalie C. Butterfield Davide Komla-Ebri Ryan C. Chai Alexander P. Corr James T. Smith Sindhu T. Mohanty John A. Morris Michelle M. McDonald Julian M. W. Quinn Amelia R. McGlade Nenad Bartonicek Matt Jansson Konstantinos Hatzikotoulas Melita D. Irving Ana Beleza-Meireles Fernando Rivadeneira Emma Duncan J. Brent Richards David J. Adams Christopher J. Lelliott Robert Brink Tri Giang Phan John A. Eisman David M. Evans Eleftheria Zeggini Paul A. Baldock J. H. Duncan Bassett Graham R. Williams Peter I. Croucher |
| author_sort |
Scott E. Youlten |
| title |
Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease |
| title_short |
Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease |
| title_full |
Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease |
| title_fullStr |
Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease |
| title_full_unstemmed |
Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease |
| title_sort |
osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/60182d9a653b4b4d9d0b7b34378bcb3e |
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