Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells.
<h4>Background</h4>Virus-specific CD8(+) T lymphocytes play a key role in the initial reduction of peak viremia during acute viral infections, but display signs of increasing dysfunction and exhaustion under conditions of chronic antigen persistence. It has been suggested that virus-spec...
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| Auteurs principaux: | , , , , , , , , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Public Library of Science (PLoS)
2008
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| Accès en ligne: | https://doaj.org/article/601de8e1963547e5b824c9a368473863 |
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