Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells.

Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells.

<h4>Background</h4>Virus-specific CD8(+) T lymphocytes play a key role in the initial reduction of peak viremia during acute viral infections, but display signs of increasing dysfunction and exhaustion under conditions of chronic antigen persistence. It has been suggested that virus-spec...

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Main Authors: Hendrik Streeck, Zabrina L Brumme, Michael Anastario, Kristin W Cohen, Jonathan S Jolin, Angela Meier, Chanson J Brumme, Eric S Rosenberg, Galit Alter, Todd M Allen, Bruce D Walker, Marcus Altfeld
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2008
Subjects:
Medicine
R
Online Access:https://doaj.org/article/601de8e1963547e5b824c9a368473863
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https://doaj.org/article/601de8e1963547e5b824c9a368473863

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