Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E2 synthesis in the brain and their behavioral relevance

Abstract Inflammation in the brain and periphery has been associated with stress-related pathology of mental illness. We have shown that prostaglandin (PG) E2, an arachidonic acid-derived lipid mediator, and innate immune receptors Toll-like receptor (TLR) 2/4 are crucial for repeated stress-induced...

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Bibliographic Details
Main Authors: Xiang Nie, Shiho Kitaoka, Masakazu Shinohara, Akira Kakizuka, Shuh Narumiya, Tomoyuki Furuyashiki
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
R
Q
Online Access:https://doaj.org/article/60260c3f54e345d4b0c7bfbf9609e0e9
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