Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice

Abstract Lamellipodin (Lpd) functions as an important signalling integrator downstream of growth factor and axon guidance receptors. Mechanistically, Lpd promotes actin polymerization by interacting with F-actin and the actin effectors Ena/VASP proteins and the SCAR/WAVE complex. Thereby, Lpd suppor...

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Autores principales:	Cristian Bodo, Cathy Fernandes, Matthias Krause
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/602c36a7f5d1499a9eb0309abd188dfd
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spelling	oai:doaj.org-article:602c36a7f5d1499a9eb0309abd188dfd2021-12-02T11:40:30ZBrain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice10.1038/s41598-017-05043-32045-2322https://doaj.org/article/602c36a7f5d1499a9eb0309abd188dfd2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05043-3https://doaj.org/toc/2045-2322Abstract Lamellipodin (Lpd) functions as an important signalling integrator downstream of growth factor and axon guidance receptors. Mechanistically, Lpd promotes actin polymerization by interacting with F-actin and the actin effectors Ena/VASP proteins and the SCAR/WAVE complex. Thereby, Lpd supports lamellipodia protrusion, cell migration and endocytosis. In the mammalian central nervous system, Lpd contributes to neuronal morphogenesis, neuronal migration during development and its C. elegans orthologue MIG-10 also supports synaptogenesis. However, the consequences of loss of Lpd in the CNS on behaviour are unknown. In our current study, we crossed our Lpd conditional knockout mice with a mouse line expressing Cre under the CNS specific Nestin promoter to restrict the genetic ablation of Lpd to the central nervous system. Detailed behavioural analysis of the resulting Nestin-Cre-Lpd knockout mouse line revealed a specific behavioural phenotype characterised by hyperactivity and increased anxiety.Cristian BodoCathy FernandesMatthias KrauseNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cristian Bodo Cathy Fernandes Matthias Krause Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice
description	Abstract Lamellipodin (Lpd) functions as an important signalling integrator downstream of growth factor and axon guidance receptors. Mechanistically, Lpd promotes actin polymerization by interacting with F-actin and the actin effectors Ena/VASP proteins and the SCAR/WAVE complex. Thereby, Lpd supports lamellipodia protrusion, cell migration and endocytosis. In the mammalian central nervous system, Lpd contributes to neuronal morphogenesis, neuronal migration during development and its C. elegans orthologue MIG-10 also supports synaptogenesis. However, the consequences of loss of Lpd in the CNS on behaviour are unknown. In our current study, we crossed our Lpd conditional knockout mice with a mouse line expressing Cre under the CNS specific Nestin promoter to restrict the genetic ablation of Lpd to the central nervous system. Detailed behavioural analysis of the resulting Nestin-Cre-Lpd knockout mouse line revealed a specific behavioural phenotype characterised by hyperactivity and increased anxiety.
format	article
author	Cristian Bodo Cathy Fernandes Matthias Krause
author_facet	Cristian Bodo Cathy Fernandes Matthias Krause
author_sort	Cristian Bodo
title	Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice
title_short	Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice
title_full	Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice
title_fullStr	Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice
title_full_unstemmed	Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice
title_sort	brain specific lamellipodin knockout results in hyperactivity and increased anxiety of mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/602c36a7f5d1499a9eb0309abd188dfd
work_keys_str_mv	AT cristianbodo brainspecificlamellipodinknockoutresultsinhyperactivityandincreasedanxietyofmice AT cathyfernandes brainspecificlamellipodinknockoutresultsinhyperactivityandincreasedanxietyofmice AT matthiaskrause brainspecificlamellipodinknockoutresultsinhyperactivityandincreasedanxietyofmice
_version_	1718395583385829376

Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice

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