Didehydro-Cortistatin A Inhibits HIV-1 by Specifically Binding to the Unstructured Basic Region of Tat

Didehydro-Cortistatin A Inhibits HIV-1 by Specifically Binding to the Unstructured Basic Region of Tat

ABSTRACT The intrinsically disordered HIV-1 Tat protein binds the viral RNA transactivation response structure (TAR), which recruits transcriptional cofactors, amplifying viral mRNA expression. Limited Tat transactivation correlates with HIV-1 latency. Unfortunately, Tat inhibitors are not clinicall...

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Main Authors: Sonia Mediouni, Krishna Chinthalapudi, Mary K. Ekka, Ippei Usui, Joseph A. Jablonski, Mark A. Clementz, Guillaume Mousseau, Jason Nowak, Venkat R. Macherla, Jacob N. Beverage, Eduardo Esquenazi, Phil Baran, Ian Mitchelle S. de Vera, Douglas Kojetin, Erwann P. Loret, Kendall Nettles, Souvik Maiti, Tina Izard, Susana T. Valente
Format: article
Language:EN
Published: American Society for Microbiology 2019
Subjects:
HIV-1 Tat
structure-activity relationship
dCA
molecular docking
structure-based design
Microbiology
QR1-502
Online Access:https://doaj.org/article/602de632323a423fab4a3dba4bf5eaf7
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https://doaj.org/article/602de632323a423fab4a3dba4bf5eaf7

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