An HIV Vaccine Protective Allele in FCGR2C Associates With Increased Odds of Perinatal HIV Acquisition

In the Thai RV144 HIV-1 vaccine trial, a three-variant haplotype within the Fc gamma receptor 2C gene (FCGR2C) reduced the risk of HIV-1 acquisition. A follow-on trial, HVTN702, of a similar vaccine candidate found no efficacy in South Africa, where the predominant population is polymorphic for only...

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Bibliographic Details
Main Authors: Joy Ebonwu, Ria Lassaunière, Maria Paximadis, Mark Goosen, Renate Strehlau, Glenda E. Gray, Louise Kuhn, Caroline T. Tiemessen
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
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Online Access:https://doaj.org/article/606f17dc663147008740c3e9a01e0b5c
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