GSA: an independent development algorithm for calling copy number and detecting homologous recombination deficiency (HRD) from target capture sequencing

GSA: an independent development algorithm for calling copy number and detecting homologous recombination deficiency (HRD) from target capture sequencing

Abstract Background The gain or loss of large chromosomal regions or even whole chromosomes is termed as genomic scarring and can be observed as copy number variations resulting from the failure of DNA damage repair. Results In this study, a new algorithm called genomic scar analysis (GSA) has devel...

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Autores principales: Dongju Chen, Minghui Shao, Pei Meng, Chunli Wang, Qi Li, Yuhang Cai, Chengcheng Song, Xi Wang, Taiping Shi
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Copy number variations
Segmentation
Tumor purity and ploidy correction
Genomic scar analysis
Homologous recombination deficiency
Computer applications to medicine. Medical informatics
R858-859.7
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/60743a88821147f489c4a6aab493a66a
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https://doaj.org/article/60743a88821147f489c4a6aab493a66a

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