Monitoring Tacrolimus Concentrations in Whole Blood and Peripheral Blood Mononuclear Cells: Inter- and Intra-Patient Variability in a Cohort of Pediatric Patients

Monitoring Tacrolimus Concentrations in Whole Blood and Peripheral Blood Mononuclear Cells: Inter- and Intra-Patient Variability in a Cohort of Pediatric Patients

Tacrolimus (TAC) is a first-choice immunosuppressant for solid organ transplantation, characterized by high potential for drug-drug interactions, significant inter- and intra-patient variability, and narrow therapeutic index. Therapeutic drug monitoring (TDM) of TAC concentrations in whole blood (WB...

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Autores principales: Amedeo De Nicolò, Michele Pinon, Alice Palermiti, Antonello Nonnato, Alessandra Manca, Jacopo Mula, Silvia Catalano, Francesco Tandoi, Renato Romagnoli, Antonio D’Avolio, Pier Luigi Calvo
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
pharmacokinetics
immunosuppressant
pharmacology
pharmacokinetics-pharmacodynamics
transplantation
pharmacokinectics
Therapeutics. Pharmacology
RM1-950
Acceso en línea:https://doaj.org/article/60763e1cd80049c3a0135c3381f099e7
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https://doaj.org/article/60763e1cd80049c3a0135c3381f099e7

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