Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis

Cancer metastasis is the leading cause of death in patients, here, the authors show disrupting tumor vasculature could recruit and activate anti-PD-L1 engineered platelet at metastatic tumor sites to block the PD-1/PD-L1 crosstalk and enhance the anticancer immunotherapy.

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Autores principales: Hongjun Li, Zejun Wang, Zhaowei Chen, Tianyuan Ci, Guojun Chen, Di Wen, Ruoxin Li, Jinqiang Wang, Huan Meng, R. Bryan Bell, Zhifeng Gu, Gianpietro Dotti, Zhen Gu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/608a4349715044a79d78a3f8c89aa2c6
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