Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis

Cancer metastasis is the leading cause of death in patients, here, the authors show disrupting tumor vasculature could recruit and activate anti-PD-L1 engineered platelet at metastatic tumor sites to block the PD-1/PD-L1 crosstalk and enhance the anticancer immunotherapy.

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Autores principales:	Hongjun Li, Zejun Wang, Zhaowei Chen, Tianyuan Ci, Guojun Chen, Di Wen, Ruoxin Li, Jinqiang Wang, Huan Meng, R. Bryan Bell, Zhifeng Gu, Gianpietro Dotti, Zhen Gu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/608a4349715044a79d78a3f8c89aa2c6
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spelling	oai:doaj.org-article:608a4349715044a79d78a3f8c89aa2c62021-12-02T16:50:26ZDisrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis10.1038/s41467-021-22674-32041-1723https://doaj.org/article/608a4349715044a79d78a3f8c89aa2c62021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22674-3https://doaj.org/toc/2041-1723Cancer metastasis is the leading cause of death in patients, here, the authors show disrupting tumor vasculature could recruit and activate anti-PD-L1 engineered platelet at metastatic tumor sites to block the PD-1/PD-L1 crosstalk and enhance the anticancer immunotherapy.Hongjun LiZejun WangZhaowei ChenTianyuan CiGuojun ChenDi WenRuoxin LiJinqiang WangHuan MengR. Bryan BellZhifeng GuGianpietro DottiZhen GuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hongjun Li Zejun Wang Zhaowei Chen Tianyuan Ci Guojun Chen Di Wen Ruoxin Li Jinqiang Wang Huan Meng R. Bryan Bell Zhifeng Gu Gianpietro Dotti Zhen Gu Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis
description	Cancer metastasis is the leading cause of death in patients, here, the authors show disrupting tumor vasculature could recruit and activate anti-PD-L1 engineered platelet at metastatic tumor sites to block the PD-1/PD-L1 crosstalk and enhance the anticancer immunotherapy.
format	article
author	Hongjun Li Zejun Wang Zhaowei Chen Tianyuan Ci Guojun Chen Di Wen Ruoxin Li Jinqiang Wang Huan Meng R. Bryan Bell Zhifeng Gu Gianpietro Dotti Zhen Gu
author_facet	Hongjun Li Zejun Wang Zhaowei Chen Tianyuan Ci Guojun Chen Di Wen Ruoxin Li Jinqiang Wang Huan Meng R. Bryan Bell Zhifeng Gu Gianpietro Dotti Zhen Gu
author_sort	Hongjun Li
title	Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis
title_short	Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis
title_full	Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis
title_fullStr	Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis
title_full_unstemmed	Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis
title_sort	disrupting tumour vasculature and recruitment of apdl1-loaded platelets control tumour metastasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/608a4349715044a79d78a3f8c89aa2c6
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Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis

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