Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides

Bicyclic peptides can inhibit biological targets hard to address with small molecules. Here, the authors combine two orthogonal ring-closing reactions to produce bicyclic peptides with improved bioactivity thereby providing a strategy that can greatly improve the structural diversity of such peptide...

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Autores principales:	Philipp M. Cromm, Sebastian Schaubach, Jochen Spiegel, Alois Fürstner, Tom N. Grossmann, Herbert Waldmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6091ec26a2d4425d83166be139ae90e0
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spelling	oai:doaj.org-article:6091ec26a2d4425d83166be139ae90e02021-12-02T15:34:56ZOrthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides10.1038/ncomms113002041-1723https://doaj.org/article/6091ec26a2d4425d83166be139ae90e02016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11300https://doaj.org/toc/2041-1723Bicyclic peptides can inhibit biological targets hard to address with small molecules. Here, the authors combine two orthogonal ring-closing reactions to produce bicyclic peptides with improved bioactivity thereby providing a strategy that can greatly improve the structural diversity of such peptides.Philipp M. CrommSebastian SchaubachJochen SpiegelAlois FürstnerTom N. GrossmannHerbert WaldmannNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Philipp M. Cromm Sebastian Schaubach Jochen Spiegel Alois Fürstner Tom N. Grossmann Herbert Waldmann Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides
description	Bicyclic peptides can inhibit biological targets hard to address with small molecules. Here, the authors combine two orthogonal ring-closing reactions to produce bicyclic peptides with improved bioactivity thereby providing a strategy that can greatly improve the structural diversity of such peptides.
format	article
author	Philipp M. Cromm Sebastian Schaubach Jochen Spiegel Alois Fürstner Tom N. Grossmann Herbert Waldmann
author_facet	Philipp M. Cromm Sebastian Schaubach Jochen Spiegel Alois Fürstner Tom N. Grossmann Herbert Waldmann
author_sort	Philipp M. Cromm
title	Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides
title_short	Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides
title_full	Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides
title_fullStr	Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides
title_full_unstemmed	Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides
title_sort	orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small gtpase-targeting bicyclic peptides
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6091ec26a2d4425d83166be139ae90e0
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Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides

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