Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides

Bicyclic peptides can inhibit biological targets hard to address with small molecules. Here, the authors combine two orthogonal ring-closing reactions to produce bicyclic peptides with improved bioactivity thereby providing a strategy that can greatly improve the structural diversity of such peptide...

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Autores principales: Philipp M. Cromm, Sebastian Schaubach, Jochen Spiegel, Alois Fürstner, Tom N. Grossmann, Herbert Waldmann
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/6091ec26a2d4425d83166be139ae90e0
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