Improving formaldehyde consumption drives methanol assimilation in engineered E. coli

Engineering E. coli for metabolization of methanol to produce fuels and chemicals has not been fully achieved. Here, the authors combine metabolic engineering and chemical inhibition to improve methanol assimilation and distinguish the role of kinetics and thermodynamics under various culture condit...

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Auteurs principaux:	Benjamin M. Woolston, Jason R. King, Michael Reiter, Bob Van Hove, Gregory Stephanopoulos
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/60acd311edfb421fb3ff1741090fb9a0
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spelling	oai:doaj.org-article:60acd311edfb421fb3ff1741090fb9a02021-12-02T15:34:26ZImproving formaldehyde consumption drives methanol assimilation in engineered E. coli10.1038/s41467-018-04795-42041-1723https://doaj.org/article/60acd311edfb421fb3ff1741090fb9a02018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04795-4https://doaj.org/toc/2041-1723Engineering E. coli for metabolization of methanol to produce fuels and chemicals has not been fully achieved. Here, the authors combine metabolic engineering and chemical inhibition to improve methanol assimilation and distinguish the role of kinetics and thermodynamics under various culture conditions.Benjamin M. WoolstonJason R. KingMichael ReiterBob Van HoveGregory StephanopoulosNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin M. Woolston Jason R. King Michael Reiter Bob Van Hove Gregory Stephanopoulos Improving formaldehyde consumption drives methanol assimilation in engineered E. coli
description	Engineering E. coli for metabolization of methanol to produce fuels and chemicals has not been fully achieved. Here, the authors combine metabolic engineering and chemical inhibition to improve methanol assimilation and distinguish the role of kinetics and thermodynamics under various culture conditions.
format	article
author	Benjamin M. Woolston Jason R. King Michael Reiter Bob Van Hove Gregory Stephanopoulos
author_facet	Benjamin M. Woolston Jason R. King Michael Reiter Bob Van Hove Gregory Stephanopoulos
author_sort	Benjamin M. Woolston
title	Improving formaldehyde consumption drives methanol assimilation in engineered E. coli
title_short	Improving formaldehyde consumption drives methanol assimilation in engineered E. coli
title_full	Improving formaldehyde consumption drives methanol assimilation in engineered E. coli
title_fullStr	Improving formaldehyde consumption drives methanol assimilation in engineered E. coli
title_full_unstemmed	Improving formaldehyde consumption drives methanol assimilation in engineered E. coli
title_sort	improving formaldehyde consumption drives methanol assimilation in engineered e. coli
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/60acd311edfb421fb3ff1741090fb9a0
work_keys_str_mv	AT benjaminmwoolston improvingformaldehydeconsumptiondrivesmethanolassimilationinengineeredecoli AT jasonrking improvingformaldehydeconsumptiondrivesmethanolassimilationinengineeredecoli AT michaelreiter improvingformaldehydeconsumptiondrivesmethanolassimilationinengineeredecoli AT bobvanhove improvingformaldehydeconsumptiondrivesmethanolassimilationinengineeredecoli AT gregorystephanopoulos improvingformaldehydeconsumptiondrivesmethanolassimilationinengineeredecoli
_version_	1718386839350411264

Improving formaldehyde consumption drives methanol assimilation in engineered E. coli

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