Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells

Pertussis toxin enhances the induction of autoreactive T cells in mouse models of autoimmunity. Here the authors show that stimulation of IL-1β production in myeloid cells by pertussis toxin is necessary to prime pathogenic Th1/Th17 cells in experimental autoimmune encephalopathy.

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Auteurs principaux: Francesca Ronchi, Camilla Basso, Silvia Preite, Andrea Reboldi, Dirk Baumjohann, Luana Perlini, Antonio Lanzavecchia, Federica Sallusto
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Accès en ligne:https://doaj.org/article/60aea11e72f949ae8b88198b96e820eb
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