Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells

Pertussis toxin enhances the induction of autoreactive T cells in mouse models of autoimmunity. Here the authors show that stimulation of IL-1β production in myeloid cells by pertussis toxin is necessary to prime pathogenic Th1/Th17 cells in experimental autoimmune encephalopathy.

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Autores principales:	Francesca Ronchi, Camilla Basso, Silvia Preite, Andrea Reboldi, Dirk Baumjohann, Luana Perlini, Antonio Lanzavecchia, Federica Sallusto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/60aea11e72f949ae8b88198b96e820eb
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spelling	oai:doaj.org-article:60aea11e72f949ae8b88198b96e820eb2021-12-02T15:35:26ZExperimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells10.1038/ncomms115412041-1723https://doaj.org/article/60aea11e72f949ae8b88198b96e820eb2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11541https://doaj.org/toc/2041-1723Pertussis toxin enhances the induction of autoreactive T cells in mouse models of autoimmunity. Here the authors show that stimulation of IL-1β production in myeloid cells by pertussis toxin is necessary to prime pathogenic Th1/Th17 cells in experimental autoimmune encephalopathy.Francesca RonchiCamilla BassoSilvia PreiteAndrea ReboldiDirk BaumjohannLuana PerliniAntonio LanzavecchiaFederica SallustoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Francesca Ronchi Camilla Basso Silvia Preite Andrea Reboldi Dirk Baumjohann Luana Perlini Antonio Lanzavecchia Federica Sallusto Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells
description	Pertussis toxin enhances the induction of autoreactive T cells in mouse models of autoimmunity. Here the authors show that stimulation of IL-1β production in myeloid cells by pertussis toxin is necessary to prime pathogenic Th1/Th17 cells in experimental autoimmune encephalopathy.
format	article
author	Francesca Ronchi Camilla Basso Silvia Preite Andrea Reboldi Dirk Baumjohann Luana Perlini Antonio Lanzavecchia Federica Sallusto
author_facet	Francesca Ronchi Camilla Basso Silvia Preite Andrea Reboldi Dirk Baumjohann Luana Perlini Antonio Lanzavecchia Federica Sallusto
author_sort	Francesca Ronchi
title	Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells
title_short	Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells
title_full	Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells
title_fullStr	Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells
title_full_unstemmed	Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells
title_sort	experimental priming of encephalitogenic th1/th17 cells requires pertussis toxin-driven il-1β production by myeloid cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/60aea11e72f949ae8b88198b96e820eb
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Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells

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