A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors

A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors

Summary: Receptor clustering is the first and critical step to activate apoptosis by death receptor-5 (DR5). The recent discovery of the autoinhibitory DR5 ectodomain has challenged the long-standing view of its mechanistic activation by the natural ligand Apo2L. Because the autoinhibitory residues...

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Bibliographic Details
Main Authors: Gururaj Shivange, Tanmoy Mondal, Evan Lyerly, Sanchita Bhatnagar, Charles N. Landen, Shivani Reddy, Jonathan Kim, Britney Doan, Paula Riddle, Jogender Tushir-Singh
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
TNF superfamily
receptor clustering
death receptor
ovarian tumors
TNBC
solid tumors
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/60c0e8c51e324df1a195182838329e2c
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https://doaj.org/article/60c0e8c51e324df1a195182838329e2c

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