Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone

The Hsp70/Hsp40 system plays an important role in maintaining cellular proteostasis but so far it is not well understood how Hsp70 proteins are recruited to specific Hsp40 co-chaperones. Here, the authors combine biochemical and biophysical approaches to characterise the oligomeric mammalian Hsp40 D...

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Bibliographic Details
Main Authors: Bryan D. Ryder, Irina Matlahov, Sofia Bali, Jaime Vaquer-Alicea, Patrick C. A. van der Wel, Lukasz A. Joachimiak
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/60d78f39be754f40b8a931a46a1f1dfb
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