Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone

The Hsp70/Hsp40 system plays an important role in maintaining cellular proteostasis but so far it is not well understood how Hsp70 proteins are recruited to specific Hsp40 co-chaperones. Here, the authors combine biochemical and biophysical approaches to characterise the oligomeric mammalian Hsp40 D...

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Autores principales:	Bryan D. Ryder, Irina Matlahov, Sofia Bali, Jaime Vaquer-Alicea, Patrick C. A. van der Wel, Lukasz A. Joachimiak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/60d78f39be754f40b8a931a46a1f1dfb
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spelling	oai:doaj.org-article:60d78f39be754f40b8a931a46a1f1dfb2021-12-02T14:10:56ZRegulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone10.1038/s41467-021-21147-x2041-1723https://doaj.org/article/60d78f39be754f40b8a931a46a1f1dfb2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21147-xhttps://doaj.org/toc/2041-1723The Hsp70/Hsp40 system plays an important role in maintaining cellular proteostasis but so far it is not well understood how Hsp70 proteins are recruited to specific Hsp40 co-chaperones. Here, the authors combine biochemical and biophysical approaches to characterise the oligomeric mammalian Hsp40 DnaJB8. They identify an intra-oligomer DnaJB8 interaction between the N-terminal J-Domain and the C-terminal domain that occludes the J-Domain surface that binds Hsp70 and propose a model for DnaJB8-Hsp70 recruitment.Bryan D. RyderIrina MatlahovSofia BaliJaime Vaquer-AliceaPatrick C. A. van der WelLukasz A. JoachimiakNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bryan D. Ryder Irina Matlahov Sofia Bali Jaime Vaquer-Alicea Patrick C. A. van der Wel Lukasz A. Joachimiak Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone
description	The Hsp70/Hsp40 system plays an important role in maintaining cellular proteostasis but so far it is not well understood how Hsp70 proteins are recruited to specific Hsp40 co-chaperones. Here, the authors combine biochemical and biophysical approaches to characterise the oligomeric mammalian Hsp40 DnaJB8. They identify an intra-oligomer DnaJB8 interaction between the N-terminal J-Domain and the C-terminal domain that occludes the J-Domain surface that binds Hsp70 and propose a model for DnaJB8-Hsp70 recruitment.
format	article
author	Bryan D. Ryder Irina Matlahov Sofia Bali Jaime Vaquer-Alicea Patrick C. A. van der Wel Lukasz A. Joachimiak
author_facet	Bryan D. Ryder Irina Matlahov Sofia Bali Jaime Vaquer-Alicea Patrick C. A. van der Wel Lukasz A. Joachimiak
author_sort	Bryan D. Ryder
title	Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone
title_short	Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone
title_full	Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone
title_fullStr	Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone
title_full_unstemmed	Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone
title_sort	regulatory inter-domain interactions influence hsp70 recruitment to the dnajb8 chaperone
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/60d78f39be754f40b8a931a46a1f1dfb
work_keys_str_mv	AT bryandryder regulatoryinterdomaininteractionsinfluencehsp70recruitmenttothednajb8chaperone AT irinamatlahov regulatoryinterdomaininteractionsinfluencehsp70recruitmenttothednajb8chaperone AT sofiabali regulatoryinterdomaininteractionsinfluencehsp70recruitmenttothednajb8chaperone AT jaimevaqueralicea regulatoryinterdomaininteractionsinfluencehsp70recruitmenttothednajb8chaperone AT patrickcavanderwel regulatoryinterdomaininteractionsinfluencehsp70recruitmenttothednajb8chaperone AT lukaszajoachimiak regulatoryinterdomaininteractionsinfluencehsp70recruitmenttothednajb8chaperone
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Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone

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