Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota

Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota

Here, the authors designed a lipopeptide, Pam-3, based on an eight-amino acid carboxyl-terminal fragment of human β-defensin 1 with prominent antimicrobial activity against multidrug-resistant ESKAPE pathogens and antibiofilm properties. They show in mouse models, that Pam-3 selectively reduced acut...

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Bibliographic Details
Main Authors: Louis Koeninger, Lisa Osbelt, Anne Berscheid, Judith Wendler, Jürgen Berger, Katharina Hipp, Till R. Lesker, Marina C. Pils, Nisar P. Malek, Benjamin A. H. Jensen, Heike Brötz-Oesterhelt, Till Strowig, Jan Wehkamp
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/60e06fcc0c004de2888235e5c6c874e7
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https://doaj.org/article/60e06fcc0c004de2888235e5c6c874e7

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