Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota

Here, the authors designed a lipopeptide, Pam-3, based on an eight-amino acid carboxyl-terminal fragment of human β-defensin 1 with prominent antimicrobial activity against multidrug-resistant ESKAPE pathogens and antibiofilm properties. They show in mouse models, that Pam-3 selectively reduced acut...

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Autores principales:	Louis Koeninger, Lisa Osbelt, Anne Berscheid, Judith Wendler, Jürgen Berger, Katharina Hipp, Till R. Lesker, Marina C. Pils, Nisar P. Malek, Benjamin A. H. Jensen, Heike Brötz-Oesterhelt, Till Strowig, Jan Wehkamp
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/60e06fcc0c004de2888235e5c6c874e7
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spelling	oai:doaj.org-article:60e06fcc0c004de2888235e5c6c874e72021-12-02T15:07:31ZCurbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota10.1038/s42003-020-01582-02399-3642https://doaj.org/article/60e06fcc0c004de2888235e5c6c874e72021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01582-0https://doaj.org/toc/2399-3642Here, the authors designed a lipopeptide, Pam-3, based on an eight-amino acid carboxyl-terminal fragment of human β-defensin 1 with prominent antimicrobial activity against multidrug-resistant ESKAPE pathogens and antibiofilm properties. They show in mouse models, that Pam-3 selectively reduced acute intestinal Salmonella and established Citrobacter infections, without compromising the core microbiota.Louis KoeningerLisa OsbeltAnne BerscheidJudith WendlerJürgen BergerKatharina HippTill R. LeskerMarina C. PilsNisar P. MalekBenjamin A. H. JensenHeike Brötz-OesterheltTill StrowigJan WehkampNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Louis Koeninger Lisa Osbelt Anne Berscheid Judith Wendler Jürgen Berger Katharina Hipp Till R. Lesker Marina C. Pils Nisar P. Malek Benjamin A. H. Jensen Heike Brötz-Oesterhelt Till Strowig Jan Wehkamp Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota
description	Here, the authors designed a lipopeptide, Pam-3, based on an eight-amino acid carboxyl-terminal fragment of human β-defensin 1 with prominent antimicrobial activity against multidrug-resistant ESKAPE pathogens and antibiofilm properties. They show in mouse models, that Pam-3 selectively reduced acute intestinal Salmonella and established Citrobacter infections, without compromising the core microbiota.
format	article
author	Louis Koeninger Lisa Osbelt Anne Berscheid Judith Wendler Jürgen Berger Katharina Hipp Till R. Lesker Marina C. Pils Nisar P. Malek Benjamin A. H. Jensen Heike Brötz-Oesterhelt Till Strowig Jan Wehkamp
author_facet	Louis Koeninger Lisa Osbelt Anne Berscheid Judith Wendler Jürgen Berger Katharina Hipp Till R. Lesker Marina C. Pils Nisar P. Malek Benjamin A. H. Jensen Heike Brötz-Oesterhelt Till Strowig Jan Wehkamp
author_sort	Louis Koeninger
title	Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota
title_short	Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota
title_full	Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota
title_fullStr	Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota
title_full_unstemmed	Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota
title_sort	curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/60e06fcc0c004de2888235e5c6c874e7
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Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota

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