Model-driven generation of artificial yeast promoters

A small set of promoters is used for most genetic construct design in S. cerevisiae. Here, the authors develop a predictive model of promoter activity trained on a data set of over one million sequences and use it to design large sets of high-activity promoters.

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Bibliographic Details
Main Authors:	Benjamin J. Kotopka, Christina D. Smolke
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/60f4d5679ca14b2e8e6f8ec1bb4c67b7
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spelling	oai:doaj.org-article:60f4d5679ca14b2e8e6f8ec1bb4c67b72021-12-02T15:39:22ZModel-driven generation of artificial yeast promoters10.1038/s41467-020-15977-42041-1723https://doaj.org/article/60f4d5679ca14b2e8e6f8ec1bb4c67b72020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15977-4https://doaj.org/toc/2041-1723A small set of promoters is used for most genetic construct design in S. cerevisiae. Here, the authors develop a predictive model of promoter activity trained on a data set of over one million sequences and use it to design large sets of high-activity promoters.Benjamin J. KotopkaChristina D. SmolkeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin J. Kotopka Christina D. Smolke Model-driven generation of artificial yeast promoters
description	A small set of promoters is used for most genetic construct design in S. cerevisiae. Here, the authors develop a predictive model of promoter activity trained on a data set of over one million sequences and use it to design large sets of high-activity promoters.
format	article
author	Benjamin J. Kotopka Christina D. Smolke
author_facet	Benjamin J. Kotopka Christina D. Smolke
author_sort	Benjamin J. Kotopka
title	Model-driven generation of artificial yeast promoters
title_short	Model-driven generation of artificial yeast promoters
title_full	Model-driven generation of artificial yeast promoters
title_fullStr	Model-driven generation of artificial yeast promoters
title_full_unstemmed	Model-driven generation of artificial yeast promoters
title_sort	model-driven generation of artificial yeast promoters
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/60f4d5679ca14b2e8e6f8ec1bb4c67b7
work_keys_str_mv	AT benjaminjkotopka modeldrivengenerationofartificialyeastpromoters AT christinadsmolke modeldrivengenerationofartificialyeastpromoters
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Model-driven generation of artificial yeast promoters

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